Primatene Mist is an over-the-counter inhaler that contains epinephrine and is meant for short-term relief of mild asthma symptoms.

It was returned to the U.S. market in 2018 after earlier versions were removed because of propellant rules. The current product uses an FDA-approved propellant and is labeled for temporary relief, not as a long-term controller. Know when it makes sense to try Primatene and when you need a prescription inhaler.

Use and limits: Primatene gives quick bronchodilation by tightening open airways, so it can ease wheeze, cough, or shortness of breath from mild attacks. It is not suitable for severe attacks, where you should seek emergency care and use a prescribed rescue inhaler.

Who should avoid Primatene: people with heart disease, high blood pressure, thyroid problems, diabetes, or those taking certain medications should check with a doctor before use. Side effects are usually short lived but can include rapid heartbeat, shakiness, headache, or jitteriness. That's why reading the label, testing the inhaler once before relying on it, and noting any strong reactions matters.

How to use: follow the package directions exactly, prime the inhaler as shown, take the recommended number of inhalations, wait the suggested interval before repeating, and don’t exceed the max daily dose. If symptoms come back quickly after a dose or you need it often, call your healthcare provider — you may need a prescription controller or a different rescue medicine.

Compare to albuterol: Primatene uses epinephrine, which acts on a wider set of receptors than albuterol. That can mean faster relief for some, but also more cardiovascular side effects for others.

Practical tips: keep the inhaler at room temperature, check the expiry date, and carry it only if your doctor says it’s safe for you. Don’t share inhalers; infections and dosing mistakes can happen. Buy smart: Primatene is available in many pharmacies and online retailers, but read reviews and confirm the seller is reputable. If cost is an issue, ask your pharmacist about cheaper prescription options or assistance programs.

When to see a doctor: increased rescue inhaler use, waking at night with symptoms, or limits on activity mean your asthma may not be controlled. If you have sudden severe symptoms like trouble speaking, blue lips, or collapsing, call emergency services immediately.

Usage checklist

Before you use Primatene, confirm your diagnosis, review other meds, read the label, and plan when to seek help.

When to get help

If you need more than two or three doses in a day, or your rescue inhaler doesn’t work well, arrange a doctor visit within days, not weeks. Also ask about an asthma action plan—simple steps to follow when symptoms change.

Keep records: note when you use Primatene and what helped. That info makes visits more useful and can change treatment fast. Talk openly with your clinician about risks and options.