Amantadine: what it is and why people still use it

Amantadine began as an antiviral but many people today know it for treating movement problems in Parkinson’s disease and levodopa-induced dyskinesia. If you or a loved one were prescribed amantadine, you probably want straight answers: how it helps, what to watch for, and how to take it safely. This guide gives practical, down-to-earth info you can use when talking with your doctor or pharmacist.

What amantadine treats and how it works

Amantadine is used for three main reasons: short-term treatment of influenza A (though resistance has limited this use), reducing involuntary movements caused by levodopa in Parkinson’s (an extended‑release version called Gocovri is approved for this), and sometimes to ease fatigue or certain movement problems. It works by affecting brain chemicals that control movement and by interfering with viral replication when used as an antiviral. The exact way it reduces dyskinesia isn’t fully clear, but many patients notice fewer sudden, jerky movements after a few weeks.

Typical dosing, adjustments, and practical tips

Immediate‑release tablets are often started at 100 mg once or twice a day, with doctors adjusting based on response and side effects. Gocovri (extended‑release) is usually given once at bedtime at a fixed dose to target daytime dyskinesia. Kidney function matters: your doctor will lower doses if your kidneys don’t work well because the drug leaves the body through the kidneys. Don’t stop amantadine suddenly—doctors taper it to avoid withdrawal or worsening symptoms.

Take amantadine with or without food, but keep a steady schedule so levels stay even. If you miss a dose, take it when you remember unless it’s almost time for the next one. Store it at room temperature and keep it away from kids and pets.

Watch for common side effects: dizziness, trouble sleeping, dry mouth, constipation, or lightheadedness when standing. Some people develop swelling in the legs or a mottled skin pattern called livedo reticularis—mention this to your clinician. More serious reactions include confusion, hallucinations, sudden mood changes, or heart rhythm issues—call your provider right away if these occur.

Amantadine interacts with other drugs that affect the brain and blood pressure. Combining it with anticholinergic drugs, other dopaminergic agents, or strong stimulants can increase side effects. Tell your prescriber about all medicines, supplements, and herbal products you use.

Special groups: older adults are more sensitive to side effects and need careful monitoring. Pregnant or breastfeeding people should discuss risks versus benefits—information is limited. Always follow lab or kidney checks your doctor orders.

If you want to know whether amantadine is right for you, ask specifically how quickly you might see benefit, what dose adjustments are likely, and which side effects to report immediately. That gives you clear expectations and makes follow-up visits much more useful.