Sceletium (kanna) — What we published in May 2024

In May 2024 we focused on Sceletium, a South African plant that’s become a popular dietary supplement for mood and stress. The main post walks through where it comes from, how people traditionally used it, what modern research says, and practical tips for using it safely. If you want a quick, usable rundown without dense science, this archive page sums up the essentials.

What Sceletium is and how it works

Sceletium tortuosum, often called kanna, has been used by indigenous communities for mood and calming effects. Today it appears in capsules, powders, and standardized extracts like Zembrin. Modern research points to a few ways it may act in the brain: modest serotonin reuptake inhibition and effects on PDE4 and other signaling pathways. A randomized, placebo-controlled trial of a standardized extract reported reduced stress and better mood in healthy adults, which helped drive interest in clinically tested extracts.

That doesn’t mean it’s a magic fix. Effects tend to be subtle and best for mild-to-moderate stress or situational anxiety, not severe depression. People report improved relaxation, clearer thinking under stress, and better sleep when used carefully.

Practical tips: forms, dosing, safety

Forms: You’ll see whole-plant powder, tinctures, and standardized extracts. Standardized extracts (branded products) are easier to dose and backed by some clinical data. Powders are more variable—quality and alkaloid levels change by source.

Dosing: Clinical work with standardized extracts used relatively low doses. If you try Sceletium, start low and see how you feel. For branded extracts, follow the label—many trials used a single small daily dose. For powders, follow the manufacturer and start at the lowest recommended amount. Never mix it with prescription antidepressants without medical advice.

Safety and interactions: Sceletium can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonin-active drugs. Combining them raises the risk of serotonin-related side effects. Common mild side effects include nausea, headache, and lightheadedness. Avoid during pregnancy and breastfeeding unless cleared by a clinician. If you have a history of bipolar disorder, talk to your doctor before use.

Where to buy: Choose suppliers that provide third-party testing and clear extract standardization. Labels should list the botanical name (Sceletium tortuosum) and, if applicable, the extract name. Products with transparent COAs (Certificates of Analysis) are preferable.

Want more detail? Read the full May 2024 article on MapleLeafMeds.com for a deeper look at the history, study summaries, and step-by-step guidance for integrating Sceletium into a wellness routine. If you’re considering it alongside other meds or supplements, get personalized medical advice first.